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    • 专利摘要:
    Read network topology for matrix output device with a number of outputs given by the crossed combination of "m" rows and columns "n", which comprises a basic filtering block, replicated for all outputs, and assigned separately to each; each filtering block contains two filtering circuits that have a common input connection to their assigned matrix output and that provide two separate, symmetric and filtered outputs; all the row outputs (I) coming from the same row "i", but from different columns are connected to each other to an input of an amplifier linked to the row "i", and all the column outputs (j) coming from the same column "J", but different rows, are connected together to an input of an amplifier linked to the column "J", the complete topology appears revealed by expanding "i" and "J" in their respective intervals. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2629096A1
    申请号:ES201531953
    申请日:2015-12-31
    公开日:2017-08-07
    发明作者:Liczandro HERNÁNDEZ HERNÁNDEZ；Antonio Javier GONZÁLEZ MARTÍNEZ；Albert AGUILAR TALENS；José María Benlloch Baviera；Noriel Pavón Hernández
    申请人:Consejo Superior de Investigaciones Cientificas CSIC；Universidad Politecnica de Valencia；General Equipment for Medical Imaging SA；
    IPC主号:
    专利说明:

    Field of the Invention
    The present invention relates to a reading network topology for matrix output devices, useful in different sectors, and especially in the field of nuclear medicine. Background of the invention.
    The present invention relates to a reading system for a matrix output device (MOD), which provides adequate filtering of the sensor output noise and prevents mixing of the signal from the different sensor outputs, preserving the useful part of the signals in a way that it may be possible to reproduce the distribution of sensor output signals through the matrix, which requires substantially fewer amplifiers than other traditional reading systems that used to amplify each output channel.
    Position Sensitive Photomultiplier Tubes (PSPMT) are MOD well known in the art. These have a photosensitive matrix output that converts light photons into electrical currents. The main components of a PSPMT are an input window, a photocathode, focusing electrodes, nodes and an anode. The photocathode is used to convert incoming light (photons) into electrons. These photoelectrons, which are a product of the photoelectric effect, are directed by the tension of the focusing electrodes towards the next stages of nodes. The nodes are used to multiply the electrons by the process of emission of secondary electrons. Electron gains vary from 103 to 108 depending on the number of dynode stages and interdinode voltages of the PSPMTs. The main electrical difference between a non-position sensitive photomultiplier tube (PMT) and a PSPMT is that the latter offers multiple outputs in matrix form, which are activated by emulating the same geometric position of the incident photon (gamma or X ray) on the surface of the photocathode.
    Each matrix output of the PSPMT has the behavior of a load source or a current source depending on the way the light reaches the surface of the detector.
    In general, PSPMTs can be read and digitized at each matrix output, but this requires a high number of electronic channels to be processed. An intermediate reading circuit is often used to reduce the number of electronic channels to process [US6747263 (Popov)]. In general, after the reading circuit the signals are acquired, digitized and a center of gravity algorithm (COG) is used to provide the flat coordinates of the light distribution center in the photocathode [S. Siegel et al., "Simple Charge Division Readouts for Imaging Scintillator Arrays using a Multi-Channel PMT" ("Simple split-load readings for scintillator sets of image taking using a multi-channel PMT", IEEE TNS, Vol. 43, No 3 , p. 1634, June 1996], (Siegel).
    Some advanced reading electronics are able to provide, not only the light distribution center, but also information about the way of light distribution, allowing for more detailed analysis, such as determining the depth of interaction ( DOI) [US7476864 (Christoph)].
    In recent years a new type of light detector called silicon photomultiplier (SiPM) has appeared. These detectors have an internal microscopic array of photodiodes small enough to assume that they mostly capture individual photons in each photodiode. When an individual photodiode is reached by one or more photons, it changes to its activated state, generating a fixed current, regardless of the number of photons that activate it. The SiPM adds all the outputs of similar photodiodes providing a fast analog output proportional to the number of activated photodiodes, which approximately corresponds to the number of photons that affect the SiPM.
    The SiPM output may be the anode or cathode, depending on the sign of the device polarization.
    New SiPMs are increasingly used in various applications to accurately detect visible light, for example, scintillation light, and some research groups and companies, as well as SiPM manufacturers, began creating devices that contain large sets of SiPMs, which we call SiPMA, fixed in matrix configurations with a topology similar to that of PSPMTs and often with similar dimensions, to take advantage of any possible compatibility of the systems, creating an advantageous substitute component for standard MODs, (PSPMTs ), with a faster response among other benefits. Since PSPMTs are normally connected to acquisition systems through read circuits, to reduce the necessary channels, similar or equivalent circuits are required in the case of SiPMAs.
    In the same sense as the PSPMTs, the SiPMA matrix outputs have a behavior of load sources or current sources, depending on the way in which the light reaches the surface of the detector, so in this memory we will assume and represent the outputs matrixes interchangeably as sources of charge or current.
    It is important to note a relevant difference between PSPMTs and SiPMAs, in relation to the intrinsic noise of their respective detection units, that is, each anodic output pin of the PSPMT separately PAD, and individual SiPMs: the noise of a SiPM is several orders greater than the noise of a single PMT PAD anode, creating some restrictions for the circuits connected to the matrix outputs and is more relevant in those detector configurations that produce output signals close to the intrinsic noise of the SiPMs.
    We reviewed all the reading networks available for MODs, and these were tested for the specific case of the detector block formed by SiPMAs coupled to a continuous scintillation crystal. The results were not good and we concluded that these reading networks are not suitable for this new type of detector block.
    Noise in electronic systems is generally treated with filtering circuitry. These filters can be passive or active filters that can also be classified as high pass, band pass, low pass and cut filters, according to the form of frequency attenuation produced. The liabilities are designed to produce reduction of the amplitude of the noisy signals, but these also produce some reduction of the amplitude in the useful signal. On the contrary, the use of active filters prevents the reduction of the amplitude in the useful signal and produces a better signal to noise ratio. A typical active filter stage includes a passive component (i.e., capacitor, resistor, ...) at the negative input of an operational amplifier (OpAmp) and another passive component (i.e., resistance, capacitor, ...) in the feedback loop of the operational amplifier. If we want to actively filter a defined amount of signals, we usually need the same number of active filters, while each active filter requires OpAmp with its polarization circuitry, a passive feedback loop component and a passive input component. These different active filters will have their own different outputs, so if it is necessary to add a group of them, it is necessary to add one more circuit.
    Although the MODs have an uncountable number of outputs, in the present invention we will show a filtering and addition circuit that allows filtering all the MOD outputs in a manner similar to that described above, making the filtering active and the addition process in a single stage that also shares the same OpAmp for a group of noisy input signals. In this way it is possible to use a limited number of OpAmps quite low compared to the number of MOD outputs processed.
    In US6747263, Popov describes a simple network that keeps each matrix output isolated while simultaneously extracting its signals to its corresponding row and column outputs throughout the circuit. This circuit adapts very well to the functionality of PSPMTs due to the very low noise level of the PSPMTs anode outputs, which remains low, even after mixing all of these in the Popov reading network. Trying to use the Popov network in the new MODs, (the SiPMAs) fails due to the fact that at the end of the rows and columns a large number of noise signals are added that generate a bad signal-to-noise response in all rows and columns, worsening energy resolution and spatial resolutions among other characteristics of the detector, compared to a system that processes all matrix outputs individually.
    In US2013 / 0293296 A1, Proffit proposes a diode-based network instead of the resistors previously used by Popov, with the aim of overcoming noise problems. The diodes have a threshold voltage and it is necessary to overcome it before any signal can travel through the diode, so this threshold takes into account the noise, while the actual signals are high enough to rise above the threshold and reach the exit of the network after crossing the diodes.
    The problem with the Proffit network comes from the behavior of the diodes. Since the diodes will subtract their own thresholds from any signal that passes through them, the proportion of the reduced signals at the output will be greater if the signals are close to the threshold voltage, but will be insignificant if the signals are very high in comparison with the threshold, which is characteristic of the Proffit network, limiting and conditioning its ease of use.
    This type of high level signals can usually be obtained in SiPMA connected to sets of scintillators (made of small stacked pixelated scintillation crystals). When a gamma ray reaches a pixel (among all those that are stacked within the scintillation set), although the emitted light flows everywhere, a large number of photons go to the side where the SiPMA is attached, but they will flow through the only SiPM that is in front of the touched glass (or a very limited amount of SiPMs in front of this crystal), producing high level signals.
    Although scintillation assemblies connected to matrix detectors, whether PSPMTs or SiPMAs, are very common, there is a different configuration that uses a single (or continuous) monolithic crystal connected to the aforementioned matrix detectors. This configuration offers exceptional possibilities to determine the depth of interaction of the gamma rays in the detector, which is a very important advantage in some applications that require very high spatial resolution [Christoph], without taking into account that the planar resolution is not limited by any pixel size in a crystalline set.
    The use of a continuous crystal coupled to the configuration of SiPMAs produces some of the special characteristics of the output signals that it is important to take care of when extracting these signals by any means, including a reading network.
    Following the above description about the light that travels in the pixelated crystals, when a gamma ray reaches the monolithic scintillator crystal, again the emitted light flows everywhere, once again a large number of photons will go to the side where the SiPMA, but in this case the light will flow through the monolithic crystal reaching all (or almost all) the SiPMs that are distributed along the side of the monolithic scintillator, and sharing the photons among all of them, thus producing a relatively level signal low, compared to the hypothetical signal produced by the same gamma ray that reaches a pixelated crystal, although all the signals together, in the configuration with the monolithic crystal, constitute the equivalent signal for that gamma ray in a configuration with a pixelated crystal.
    Some research groups are very active in developing SiPMA technology and trying to validate different detector configurations, including Popov, Proffit networks, among others. [TO. Gonzalez et al. . "Simulation Study of Resistor Networks Applied to an Array of 256 SiPMs." ("Simulation Study of Resistor Networks applied to a set of 256 SiPMs"). Nuclear Science, IEEE Transactions on (Vol .: 60, Number: 2)].
    When the SiPMs are arranged in a SiPMA configuration, similar to those of the PSPMT, designers are tempted to use the same previous read settings to extract and process the output signals, but this does not work properly due to the fact that the SiPMs are too loud devices [A. González et al .: "Performance study of a Wide -Area SIPM ARRAY, ASICS Controlled" ("Performance study of a wide-area SiPM set, controlled by ASICS"). IEEE Transactions on Nuclear Science, vol. 62, Number: 1]. A new reading network is needed to resolve these limitations.
    Trying to use the networks described by Siegel or Popov fails, in general, when using SiPMAs because those networks add or mix all the matrix signals, adding all the noise and worsening the signal to noise ratio. This is even worse if we use the continuous monolithic crystal in addition to the SiPMA configuration, since with the energy of the gamma rays distributed across all the SiPMs within the SiPMA, the individual output signals of the SiPMs are close to the noise level. and the output signal cannot be distinguished from noise.
    The use of the Proffit network solves part of the problems described. In the configurations that use SiPMAs plus pixelated scintillating crystals, the gain of the SiPMs can be adjusted so that the noise of all the SiPMs can be below the threshold of the diodes, which allows the signal to be triggered just at the moment when the one that real signals arrive and allows the correct processing of these, although all the outputs are affected by distortions, in a different way each one.
    On the contrary, when we try to use the Proffit network in a detector configuration that includes a continuous crystal plus a SiPMA, it similarly fails to the Popov network. Since the signals are shared among all the SiPMs in the SiPMA, they are very close to the noise level, and therefore are too affected by the signal cut-off at the threshold voltage of the diode, which makes it very difficult (if not impossible) process them and obtain usable data. In this way, a large number of SiPMs elements will result in null signals, instead of the actual values and the remaining SiPM elements will result in signals that are reduced in relevant percentages, without considering that the percentages are different for each output signal. of SiPM.
    In the present invention we filter all the output signals of the matrix device instead of cutting everything that could be below a certain threshold, solving the problems mentioned in the previous paragraph in relation to the Proffit network. In addition, our invention improves the signal-to-noise ratio in each output signal of the matrix device, compared to the Popov network, which collects all the signals, as well as all the noises, worsening the possibilities of extracting useful information from the reduced number of outputs of this network.
    The filtering capacity of the proposed reading network topology, at a very early stage of the signal processing, increases the signal-to-noise ratio, preserving the useful part of the signal, while reducing the intrinsic noise of the individual SiPMs. , before mixing these in the following stages of processing, solving the problems related to noise when using SiPMs and SiPMAs.
    When working with matrix signals that arrive from SiPMAs coupled to monolithic crystal configurations, the filtering network proposed by the present invention has a better performance than those known, such as those proposed by Proffit, because both, real signal and noise, can always be clearly characterized by their respective frequencies, regardless of their amplitudes, but cannot be distinguished by their amplitudes when the signal amplitudes approach noise, as is the case with scintillation detector blocks that include monolithic crystals.
    Brief description of the invention.
    In order to properly treat the noisy SiPMA output signals, we propose a read network topology for a matrix output device with a number of outputs given by the cross combination of "m" rows and "n" columns, labeled Source (i, j) (Source (i, j)), where "i" varies from 1 am and "j" varies from 1 an, comprising a basic filtering block, replicated for all matrix outputs, and assigned separately to each; Each filter block contains a pair of filter circuits that have a common input connection to their assigned matrix output and provide two separate, symmetrical and filtered outputs, labeled Col. (j) and Row (i) (Row (i )); all the outputs of Row (i) that come from the same row "i", but from different columns are connected to each other at the low impedance input of an amplifier linked to row "i", which completes the active filtering and the mixing topology of the entire route, producing the corresponding AmpRow output (i), and all the outputs of Column (j) from the same column "j", but from different rows, are connected together to the low impedance input of an amplifier linked to column "j", which completes the active filtering and mixing topology of the entire route, producing the corresponding AmpCol (j) output; the complete topology of the reading network is revealed by expanding "i" and "j" in their respective intervals.
    According to particular embodiments of the read network topology, the filtering block is formed by a pair of CR filtering circuits.
    According to additional particular embodiments of the read network topology, the filter block is formed by a pair of CL filter circuits.
    According to additional particular embodiments, the different common outputs of the filter blocks, for the rows, Row (i), and for the columns, Column (j), are connected to amplifier circuits of the "load" or "current" types ", with low input impedance, compared to the impedance of the filtering circuit, being at least 10 times lower
    According to additional particular embodiments, the different common outputs of the filtering blocks, for the rows, Row (i), and for the columns, Column (j), are connected to the negative inputs of the amplifier circuits and a resistor is used in the feedback loop between the OpAmp output and its negative input.
    According to additional particular embodiments, all of the different common outputs of the filter blocks, for the rows, Row (i), and for the columns, Column (j), represents all of the detector outputs to be digitized .
    According to additional particular embodiments, the different amplifier outputs for the rows, AmpRow (i), and for the columns, AmpCol (j), represent the outputs of the detector to be digitized.
    According to additional particular embodiments, a first chain of resistors interconnects the outputs of all rows, AmpRow (i) and a second chain of resistors interconnects the outputs of all columns, AmpCol (j); The ends of the resistor chains allow the position "x" and "y" to be extracted directly in real time by means of the COG algorithm. An addition circuit can be provided to sum the signals obtained at the different interconnection points of the resistor chain for the rows, AmpRow
    (i) and for the columns, AmpCol (j), which represents the second moment and is a function of the DOI, inside the continuous glass coupled to the matrix output device.
    According to additional particular embodiments, the matrix output device is selected from SiPMA, PSPMTs and APD sets. An addition circuit can be arranged to sum the signals obtained at the different interconnection points of the resistor chain for the rows, AmpRow (i) and for the columns, AmpCol (j), which represents the second moment and is a function of the DOI, inside the continuous glass coupled to the matrix output device.
    According to additional particular embodiments, the matrix output device is coupled to continuous monolithic scintillator crystals, or pixelated scintillators. An addition circuit can be arranged to sum the signals obtained at the different interconnection points of the resistor chain for the rows, AmpRow (i) and for the columns, AmpCol (j), which represents the second moment and is a function of the DOI, inside the continuous glass coupled to the matrix output device.
    According to additional particular embodiments of the device comprising the reading network, a SiPMA, PSPMTs and APD sets are selected.
    According to a preferred embodiment of the device comprising the reading network, the matrix output device is coupled to continuous monolithic scintillation crystals, preferably the MOD is a SiPMA that is coupled to a monolithic crystal.
    The present invention also relates to the use of the previously defined reading network topology, or to the use of a previously defined device, in a method for obtaining images generated by gamma ray sources.
    According to particular embodiments, the invention relates to the use of the defined reading network topology, or to the use of the previously defined device, in which the device comprises a matrix of silicon-based photomultiplier devices connected to monolithic scintillation crystals or scintillation crystals Pixelated Brief description of the drawings.
    In the figures "GND" means a ground connection.
     Fig. 1 is a diagram of the pin arrangement of a matrix output device, generally known, with "m" rows and "n" columns.
     Fig. 2a shows an example of a PSPMT, with 8 rows x 8 columns, while Fig. 2b shows an example of a SiPMA with 16 rows x 16 columns. Both represent standard matrix output devices (MOD).
     Fig. 3a and Fig. 3b are two typical polarization circuits for SiPMs.
     Fig. 4a is a circuit with the typical topology (state of the art) of an active filter, including passive components connected from the input, Source (i, l) (Source (i, j)) to the negative input of the Amplifier Operational (OpAmp), labeled as AmplifierA, and a passive feedback component connected from the OpAmp output to the negative OpAmp input.
     Fig. 4b is an example of the use of a single OpAmp to mix the multiple input signals (Source (i, 1) ... Source (i, n)), without interference with each other, and actively filtering these input signals , producing a single amplified output for each row, AmpRow (i). The operation of this circuit is similar to that described in Fig. 4a, but the passive components on the left side from the "midpoint of the active filter" are distributed throughout the entire matrix, therefore we will divide this circuit for the description as if it were made up of two parts: the left part of the active filter, which corresponds to what we call the filtering circuits, and the right part of the active filter, corresponding to the OpAmp circuitry, AmplifierA, with its resistor feedback loop, R_feedback.
     Fig. 4c is an example of the use of a single OpAmp to mix the multiple input signals (Source (1, j) ... Source (m, j)), without interference with each other, and actively filtering these input signals , producing a single amplified output for each column, AmpCol (j). This circuit is divided into two parts in a manner similar to Fig. 4b.
     Fig. 4d is a simplified diagram of the right part of the circuit of Fig. 4c
     Fig. 4e is a simplified diagram of the right part of the circuit of Fig. 4b.
     Fig. 5a is a block diagram of the filtering block, which is used as a basic building block of the read network topology composed of a pair of filtering circuits (which constitute the left part of the active filters), which They provide outputs divided into rows and columns for the subsequent amplification stage and on the right side of the active filters.
     Fig. 5b and Fig. 5c are two examples of the filter blocks. The first one uses a pair of filtering circuits with the configuration of a capacitor in series with a resistor, and the second uses a pair of filtering circuits with the configuration of a capacitor in series with an inductor.
     Fig. 6 is the general block diagram of the filter read network topology, proposed in the present invention.
     • Fig. 7 is the schematic diagram of a proposed filter read network using a pair of filter CR circuits to form the filter block.
     Fig. 8 is the schematic diagram of a proposed filter read network using a pair of filter CL circuits to form the filter block.
     Fig. 9 is the schematic diagram one of a reading network, of filtering, proposed using a pair of filtering CR circuits to form the filtering block, which also comprises resistor chains in columns and rows terminals, to apply the algorithm COG and reduce the output number of the columns + rows to only 4 signals.
     Fig. 10 is the schematic diagram of a reading, filtering network, proposed using a pair of filtering CL circuits to form the filtering block, which also comprises resistor chains in columns and rows terminals, to apply the algorithm COG and reduce the output number of the columns + rows to only 4 signals.
     Fig. 11 is the schematic diagram of a reading, filtering network, proposed using a pair of filtering CR circuits to form the filtering block, which comprises two chains of resistors in columns and rows terminals: the first chain of resistors to apply the COG algorithm and reduce the output number of columns + rows to only 4 signals, and the second string of resistors to obtain a variable depending on the interaction depth (DOI) given by an additional signal.
     Fig. 12 is the schematic diagram of a proposed reading, filtering network, using a pair of CL filtering circuits to form the filtering block, which comprises two resistor chains in Column and Rows terminals: the first chain of resistors to apply the COG algorithm and reduce the output number of Rows + Columns to only 4 signals, and the second string of resistors to obtain a variable depending on the interaction depth (DOI) given by an additional signal.
    In the figures the initials or legends that appear have the following meanings:
    R = RowC = ColumnF = Filter outputS = SourceR_f = Feedback resistance (R_feedback)Ro = Output resistance (R out)AR = Amplifier RowAC = Column AmplifierDOI = Depth of Interaction Detailed description of the invention
    GLOSSARY
    MOD: It is the acronym Matrix Output Device and has the same conventional meaning as in the prior art.
    Filtering circuit: Here is a minimum circuit block with an input connection and an output connection, which can be selected from two models, the first model that includes a capacitor in series with a resistor and the second model includes a series capacitor with an inductor.
    Filtering block: It is a basic component of the read network topology and its realizations. It is made up of a pair of similar filtering circuits, one used to generate an output signal to be processed as an information container of the row, and the other used to generate an output signal to be processed as an information container for the spine.
    Read network topology: It is a generic block diagram of an electronic network, which could generate multiple specific circuitry embodiments with similar operation.
    After reviewing all available reading networks for Matrix Output Devices (MOD) and testing them, a new reading network topology is provided, specifically to overcome problems related to the high noise level of SiPMs, which operate in a manner appropriate to the requirements of a detector block consisting of a monolithic scintillation crystal plus a SiPMA. Of course, this new read network topology (which can generate different read network configurations) can work well too (and better), with MODs that are not as restrictive as SiPMAs. Each description and each embodiment of the present invention with respect to SiPMA is assumed to be generally applicable to any MOD.
    In order to properly treat the noisy output signals of the SiPMAs, in the present invention a reading network, filtering, generic topology is proposed for Matrix Output Devices, characterized by the propagation of a basic filtering block, which is replicated throughout all matrix outputs, each filter block contains a pair of filtering circuits connected to each SiPM output by a common input connection, providing two separate, symmetrical and filtered outputs - one for each filter block -. These filtered outputs are also grouped by columns and rows to then be injected into amplifier circuit inputs, to obtain actively filtered and amplified output signals, good enough to reproduce the planar position of gamma ray impact on a monolithic crystal and the DOI , if required.
    As for Fig. 1, it represents the scheme of the pin arrangement of a general Matrix Output Device (MOD) with "m" rows and "n" columns, which is the objective of the solution proposed by the present invention. Matrix outputs are current sources, therefore, these are marked accordingly and listed in the typical matrix form as Source (ij) (Source (i, j), where "i" varies from 1 to "m" and " j "varies from 1 to" n "." m "is the number of rows and" n "is the number of columns.
    Fig. 2a is a PSPMT with 8 rows and 8 columns (64 outputs), while Fig. 2b is a SiPMA with 16 rows and 16 columns (256 outputs). Both are examples of matrix output devices and have output assemblies as shown in Fig. 1, which can benefit from the present invention in order to reduce the number of electronic channels necessary to reproduce the gamma ray coordinates detected in the scintillators coupled to these MODs.
    Each matrix element of the SiPMA is a SiPM that requires its own polarization as can be seen in Fig. 3a and Fig. 3b. The SiPM element, Dij, has a diode symbol. It tilts with the inverted polarity of Vcc through a limiting resistor of Rp (ij). The capacitor Cp (i j) has enough charge to provide the output current when the SiPM opens after a nuclear event appears. The output marked as Source (i, j) (Source (i, j)) in the circuit of the figure. 3a requires a low impedance current mode connection, while the same output in the circuit of fig. 3b requires a voltage mode connection, since the latter includes the resistor Rg (ij), which drains the SiPM current, producing a voltage source instead of a current.
    Our goal is to provide a reading network to handle the countless outputs of the MODs (labeled Source (i, j) in Fig. 1, where "i" varies from 1 to "m" and "j" varies from 1 a "n", "m" being the number of rows and "n" the number of columns) and being able to reproduce the original coordinates of the impact on the scintillator, and do so even for very noisy devices, such as SiPMA.
    In the present invention, the concept of SiPMA is widely used for simplicity as a specific example of a MOD, but in all cases it should be understood that it is generally applicable to any type of MOD.
    A good way to filter countless SiPMA outputs could be to include active filtering on any output, Source (i, j), but this will usually involve the use of a replicable circuit (such as that in Fig. 4a) with the same number of OpAmps (mxn), which increases circuit space, and energy requirements, regardless of cost. In addition, the number of filtered outputs is the same as the number of inputs (m x n), so that, if we want to reduce them, we must include an additional reading network (such as Popov, etc). Therefore, an alternative circuit is proposed instead of reproducing the circuit in the figure. 4th, for all MOD outputs, Source (i, j).
    As is known in the state of the art, a reduction of signal number to rows plus columns is possible if an appropriate mixture of signals is applied, avoiding mutual interference. To do that, we have to add the filtered signals of common rows on one side (Fig. 4b), and the common columns on the other side (Fig. 4c). Taking advantage of the low impedance of the negative input of the OpAmp (labeled AmplifierA in both circuits) in an active filter configuration; We have observed that it is possible to do the summation process (avoiding interference with each other) at the midpoint of the active filter, using a single OpAmp to actively filter all incoming signals from several filters on the left side that share OpAmp, by injecting their currents together at the negative low impedance input of OpAmp (Fig. 4b and Fig. 4c), which will also add the currents of all incoming signals. This circuit shares the OpAmp labeled as AmplifierA, and the passive component in the OpAmp feedback loop, labeled as R_feedback, while including separate passive components on the input side (Ci1r, Ci2r, ..., CinR on the Fig. 4b and C1jc, C2jc, ..., Cmjc in Fig. 4c), receiving all separate noisy signals (Source (i, 1), Source (i, n) in Fig. 4b and Source (1 , j), to Source (m, j) in Fig. 4c) and injecting their currents together (added) into the negative input of the only OpAmp labeled AmplifierA in both cases.
    As explained, this circuit functionality makes it appear as if the separate active filters were connected to each output of the MOD, therefore, in the descriptions below we will assume the existence of filters connected between each output of the MOD and the specific amplified rows: AmpRow (i) in Fig. 4b, and amplified columns: AmpCol (j) in Fig. 4c, without distinguishing that they are sharing part of the circuit.
    After the assumption of the previous paragraph and for simplicity, in the following explanation of the figures we will suppress the polarization and the components of the feedback loop in the OpAmp circuits, so that the right part of the circuits in Fig. 4b and Fig. 4c, from the marked “midpoint of the active filter”, will be replaced, respectively, by the diagrams of Fig. 4E and Fig. 4d. At the same time, each horizontally deployed passive component circuit line on the left side of the circuits of Fig. 4b and Fig. 4c, from the "midpoint of the active filter" marked, will be named as "filtering circuit" in The description, below. In addition, this filtering circuit can be of the type (CijrRijr or CijcRijc) shown in Fig. 5b or (CijrLijr or CijcLijc) shown in Fig. 5c, and therefore represented as generic boxes -Fijc, Fijr in Fig. 5a -too.
    In the present invention, a reading network, filtering, generic topology is proposed for Matrix Output Devices, composed of the expansion of a basic "filtering block" along the outputs of the entire matrix, working on set with a set of amplification circuits that comply with the following:
    one.  If the size of the MOD matrix is "m" rows and "n" columns, (mxn), like the one whose pin layout is shown in Fig. 1, then we can form the entire reading network by expanding the filter block along the matrix matrix outputs (i, j), with the proviso that the variable "i" varies from 1 to "m", while "j" varies from 1 to "n". Fig. 6 represents the diagram of a general embodiment of the proposed reading network.
    2.  The filter block contains a pair of filter circuits (Fig. 5a), which can be connected to any MOD output by the common input connection that can be seen in the upper left corner,
    marked as Source (i, j), extracting two separate, symmetrical and filtered outputs labeled Col. (j) in the upper right corner and Row (i) in the lower left corner.
    3. As can be seen in Fig. 6, the number "n" of different output signals generated by the same number of filtering circuits for the rows (Fijr), labeled as Row (I), are connected to each other and then injected at the low impedance input of the amplifiers, similar to that of Fig. 4e, (the right part of the active filter in Fig. 4b) and represented on the right side of the diagram of Fig. 6, where the signals corresponding amplified and filtered output are labeled AmpRow (i).
    Four. In a manner similar to point 3 above, (speaking of Fig. 6) the number "m" of different output signals generated by the same number of filtering circuits for columns (Fijc), labeled as Column (j), are connected to each other and then injected into the low impedance input of the amplifiers, similar to that of Fig. 4d, (the right part of the active filter in Fig. 4c) and represented at the bottom of the diagram in Fig. 6, in which the corresponding filtered and amplified output signals are labeled AmpCol. (j).
    5. What we consider "the outputs of the reading network" in Fig. 6, are the amplified outputs related to all Rows and Matrix columns, Rows + Columns being equal to the number of output channels of the reading network. These outputs are located on the lower and right sides of the schemes in Fig. 6, as well as in Fig. 7 and Fig. 8, and are labeled AmpRow (i) and AmpCol. (j).
    6. Proper acquisition and scanning electronics for the "m + n" channels and specific software are required to process all the digitized signals and provide the planar position of the detected rays (gamma or X) and the DOI, if necessary.
    As a result of the operation of the reading network described in Fig. 6, the filtering circuits that work together with the OpAmp circuits form an equivalent "active filter network" with the ability to attenuate the noisy signals that reach the inputs of the network of reading of the outputs of the MOD, Source (i, j), while the real signals of the nuclear events pass through the circuits without attenuation and are directed symmetrically only to their specific "Row (i)" output and its specific "Column (j)" output, without interfering with each other and additionally amplified to generate the corresponding amplified and filtered signals AmpRow (i) and AmpCol. (j).
    The simplest and most efficient filtering circuits for forming the filtering block mentioned in the previous general description are the CR filter presented in Fig. 5b and the CL filter presented in Fig. 5c. Such combinations reduce the variation in displacement caused by variations in temperature and noise from electronics. In all of the above descriptions, the diagram of fig. 5a can be replaced by the circuits shown in the figure. 5b and Fig. 5c. In this way we will describe specific embodiments of the present invention.
    In the preferred embodiment, the filtering circuit is composed of a capacitor in series with a resistor, to form the filtering block shown in Fig. 5b. It is easy to obtain the new circuit from Fig. 6, replacing the general filtering block (Fig. 5a), associated to each Source (i, j), with the specific "CR-based" filtering circuit of Fig. 5b. The result is the scheme in Fig. 7. The output signals of a specific MOD, Source (i, j), are symmetrically divided into two components that do not interfere with each other, nor with any other signal that arrives from an output of Different mod. One of the two components is treated by the "high pass filter" created by the passive components Cijr, Rijr and R_Feedback and the amplifier with the AmpCol (j) output, (see Fig. 4c as well). The filter cutoff frequency is given by the Cijr x R_Feedback parameter, although the maximum gain is limited by the R_Feedback / Rijr ratio, to increase the stability of the circuit. The other, of the two components, is treated by the "high pass filter" created by the passive components Cijr, Rijr and R_Feedback and the amplifier with the AmpRow (i) output, (see Fig. 4b as well). The filter cutoff frequency is given by the Cijr x R_Feedback parameter, although the maximum gain is limited by the R_Feedback / Rijr ratio, to increase the stability of the circuit.
    In an alternative embodiment, the filtering circuit is composed of a capacitor in series with an inductor, to form the filtering block shown in Fig. 5c. It is easy to obtain the new circuit from Fig. 6, replacing the general filtering block (Fig. 5a), associated to each Source (i, j), with the specific "CL-based" filtering circuit of Fig. 5c. The result is the scheme in Fig. 8. The output signals of a specific MOD, Source (i, j), are symmetrically divided into two components that do not interfere with each other, nor with any other signal that arrives from an output of Different mod. One of the two components of the signal is treated by the "bandpass filter" created by the passive components Cijr, Rijr and R_Feedback and the amplifier with the AmpCol (j) output. The central frequency of the filter is given by the parameter Cijr x Lijr. Fortunately, Lijc has the parasitic resistance R (Lijc) that limits the maximum gain is limited to the R_Feedback / R (Lijr) ratio, to increase the stability of the circuit. The other, of the two components of the signal, is treated by the "bandpass filter" created by the passive components Cijr, Rijr and R_Feedback and the amplifier with the AmpRow (i) output. ). The central frequency of the filter is given by the parameter Cijr x Lijr. And the maximum gain is limited to the ratio R_Feedback / R (Lijr), to increase the stability of the circuit, R (Lijr) being the parasitic resistance of the inductor Lijr.
    In the preferred embodiment of the present invention, the SiPMA (or MOD in general) is optically coupled to a monolithic scintillation crystal. The inputs of the reading network (Source (i, j) (using the circuit in Fig. 7), "i" varies from 1 am; "j" varies from 1 an) are connected to the matrix outputs of the SiPMA (as seen in Fig. 1 also labeled as (Source (i, j)), and the two types of filtering circuit component outputs (divided into rows and columns) are connected to the low impedance inputs of the amplifiers that complete the active filter function of the network amplified signals, labeled AmpRow (i) and AmCol. (j); (i varies from 1 am and "j" varies from 1 an) reaches a number equal to the sum of the columns and rows, and can be subsequently processed analogically or digitally to obtain the planar impact position of the gamma ray on the monolithic scintillation crystal and the DOI, if necessary. In this preferred embodiment, what we consider "the outputs of the network "are the amplifier outputs related to all Rows and Column as matrix, Rows + Columns being equal to the number of the output channel of the reading network. These outputs are located on the bottom and right sides of the scheme in Fig. 7, and labeled AmpRow (i) and AmpCol. (j).
    An alternative embodiment can be obtained from a previous preferred embodiment, replacing the circuit of Fig. 7 with the circuit of Fig. 8. The SiPMA is optically coupled to a monolithic scintillation crystal. The reading network inputs (Source (i, j) (using the circuit in Fig. 8), "i" varies from 1 am; "j" varies from 1 an) are connected to the matrix outputs of the SiPMA ( as seen in Fig. 1 also labeled as (Source (i, j)), and the two types of filtering circuit component outputs (divided into rows and columns) are connected to the low impedance inputs of the amplifiers that complete the active filter function of the network The amplified signals, labeled AmpRow (i) and AmpCol (j); (i varies from 1 am and "j" varies from 1 an) reaches a number equal to the sum of the columns and rows), and can be subsequently processed analogically or digitally to obtain the planar impact position of the gamma ray on the monolithic crystal and the DOI, if necessary. The network outputs are also found here at the bottom and right sides of the scheme in Fig. 8, and labeled AmpRow
    (i) and AmpCol.
    In both cases, the preferred or alternative embodiments, an appropriate scanning acquisition electronics is required for the "m + n" channels, and specific software to process all signals and provide the planar position of the detected beam (gamma or X) and DOI if necessary.
    In alternative embodiments (Fig. 9 and Fig. 10), from the preferred and alternative embodiments above of Fig. 7 and fig. 8; and based on the prior art (ie Popov), the amplified signals (AmpRow (i) and AmpCol. (j)) can be connected to a pair of dividing resistor chains (one for Rows, shown on the side right, and the other for Columns, shown at the bottom) to reduce the number of outputs to 4 and be able to apply the COG algorithm. The resistor chain established to calculate the X coordinate, located at the bottom, is marked R0x, R1x, R2x, .., RNx, and the outputs at its edges are marked "X-" and "X +". Similarly, the resistor chain established to calculate the Y coordinate, located on the right side, is marked R0y, R1y, R2y, .., Rmy, and the outputs at its edges are marked "Y-" e " And + ".
    The value for the X position can be calculated as X = (X +) - (X) / ((X +) + (X)) and the value for the "y" position can be calculated as Y = (Y +) - (Y -) / ((Y +) + (Y-)).
    Assuming that a continuous scintillation crystal is coupled to the SiPMA, the gamma rays that hit the scintillator will produce a light distribution over the SiPMA, activating many SiPMs at a time, which allows to obtain, not only the flat coordinates where the gamma rays they reach the scintillator, but also the DOI of the gamma ray within the scintillator. This task can be done in real time, by applying the analog processing described by [Christoph] and digitizing only one signal representing the DOI, or the reading and digitization of the individual signals of each row and column can be carried out and the determination of the shape of the light and its corresponding DOI.
    In alternative configurations (Fig. 11 and Fig. 12), starting from the two previous alternative embodiments of Fig. 9 and Fig. 10; and based on the prior art (ie Christoph), an additional pair of resistor chains (one for Rows, shown on the right side, and the other for Columns, shown at the bottom) can be connected ) on the input side to the nodes of both chains of previous resistors (connected to all AmpRows (i) and AmpCol. (j) outputs) and can be connected by the output side to an electronic addition circuit (with the AmpB tag) that adds all the voltages on those nodes, to obtain an additional signal analogically representing the DOI and labeled as a DOI signal.
    10 In this last configuration only 5 signals are digitized to provide the three-dimensional position of the gamma ray impact. (X +, X-, Y +, Y-, and DOI of the signal).
    权利要求:
    Claims (16)
    [1]
    one. A read network topology for a matrix output device with a number of outputs given by the cross combination of "m" rows and columns "n", labeled Source (i, j), where "i" varies from 1 amy "j" varies from 1 an, which comprises a basic filtering block, replicated for all matrix outputs, and assigned separately to each; Each filter block contains a pair of filter circuits that have a common input connection to their assigned matrix output and provide two separate, symmetrical and filtered outputs, labeled Col. (j) and Row (i); all the outputs of Row (i) that come from the same row "i", but from different columns are connected to each other at the low impedance input of an amplifier linked to row "i", which completes the active filtering and the mixing topology of the entire route, producing the corresponding AmpRow (i) output, and all the outputs of Column (j) from the same column "j", but different rows, are connected together to the low impedance input of a amplifier linked to column "j", which completes the active filtering and mixing topology of the entire route, producing the corresponding AmpCol (j) output; the complete topology of the reading network is revealed by expanding "i" and "j" in their respective intervals.
    [2]
    2. The read network topology according to claim 1, wherein the filtering block is formed by a pair of CR filtering circuits.
    [3]
    3. The read network topology according to claim 1, wherein the filter block is formed by a pair of CL filter circuits.
    [4]
    Four.  The read network topology according to claim 1, wherein the different common outputs of the filter blocks, for rows, Row (i), and for columns, Column (j), are connected to amplifier circuits of the types " of load "or" current ", with low input impedance, compared to the impedance of the filtering circuit, being at least 10 times lower.
    [5]
    5. The read network topology according to claim 1, wherein the different common outputs of the filter blocks, for rows, Row (i), and for columns, Column (j), are connected to the negative inputs of the circuits amplifiers and a resistor is used in the feedback loop between the OpAmp output and its negative input.
    [6]
    6. The read network topology according to claim 1, wherein all of the different common outputs of the Filtering Blocks, for rows, Row (i), and for columns, Column (j), represents all of the outputs of the detector that will be digitized.
    [7]
    7.  The read network topology according to claim 1, wherein the different amplifier outputs for the rows, AmpRow (i), and for columns, AmpCol (j), represent the outputs of the detector to be digitized.
    [8]
    8. The read network topology according to claim 7, wherein, a first chain of resistors interconnects the outputs of all rows, AmpRow (i) and a second chain of resistors interconnects the outputs of all columns, AmpCol (j) ; The ends of the resistor chains allow the position "x" and "y" to be extracted directly in real time by means of the COG algorithm.
    [9]
    9. The read network topology according to any one of claims 1 to 8, wherein the matrix output device is selected from SiPMA, PSPMTs and APD sets.
    [10]
    10. The read network topology according to any one of claims 1 to 9 wherein the matrix output device is coupled to monolithic continuous scintillation crystals, or pixelated scintillators.
    [11]
    eleven. The reading network topology according to any of claims 8 or 10, wherein an addition circuit is provided to sum the signals obtained at the different interconnection points of the resistor chain for rows, AmpRow (i) and for columns, AmpCol (j), which represents the second moment and is a function of the DOI, within the continuous crystal coupled to the matrix output device.
    [12]
    12.  A device comprising the reading network topology defined in any one of claims 1 to 11, wherein the reading network is selected from a SiPMA, PSPMTs and APD sets.
    [13]
    13. A device according to claim 12 wherein the matrix output device is coupled to continuous monolithic scintillation crystals.
    [14]
    14. A device according to claim 12 wherein the reading network is a SiPMA that is coupled to a monolithic crystal.
    [15]
    fifteen.  The use of the reading network topology defined in any one of claims 1 to 11 or the use of a device defined in any of claims 12 to 14 in a method for obtaining images generated by gamma ray sources.
    [16]
    16.  The use of the read network topology defined in any one of claims 1 to 11 or the use of a device defined in any of claims 12 to 14 wherein the device comprises silicon photomultiplier matrix devices connected to monolithic scintillator crystals or Pixelated scintillation crystals.
    Fig. 1
    Fig. 2b
    Fig. 2a Fig. 3a
    Fig. 3b
    Fig. 4a
    Fig. 4b Fig. 4c
    Fig. 4d Fig. 4e
    Fig. 5a Fig. 5b
    Fig. 5c Fig. 6 Fig. 7 Fig. 8 Fig. 9 Fig. 10 Fig. 11 Fig. 12
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    同族专利:
    公开号 | 公开日
    WO2017114998A1|2017-07-06|
    WO2017114998A8|2017-10-19|
    US20190004188A1|2019-01-03|
    WO2017114998A4|2017-08-31|
    EP3399345A1|2018-11-07|
    EP3399345A4|2019-08-14|
    US10838084B2|2020-11-17|
    ES2629096B1|2018-10-26|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    DE2154539C3|1971-11-03|1974-10-10|Philips Patentverwaltung Gmbh, 2000 Hamburg|Automatic exposure circuit of an X-ray diagnostic apparatus|
    US4622467A|1982-04-21|1986-11-11|California Institute Of Technology|System for mapping radioactive specimens|
    US5347590A|1991-06-10|1994-09-13|General Electric Company|Spatial filter for an image processing system|
    US5708269A|1995-08-15|1998-01-13|Raytheon Ti Systems, Inc.|Thermal detector and method|
    US6747263B1|2001-12-07|2004-06-08|Southeastern University Research Assn. Inc.|Matrix output device readout system|
    ES2239506B1|2003-04-10|2006-11-16|Consejo Superior Investigacion|GAMMA RAY DETECTOR WITH INTERACTION DEPTH CODING.|
    GB2451678A|2007-08-10|2009-02-11|Sensl Technologies Ltd|Silicon photomultiplier circuitry for minimal onset and recovery times|
    US8884240B1|2009-06-08|2014-11-11|Radiation Monitoring Devices, Inc.|Position sensitive solid-state photomultipliers, systems and methods|
    DE102012000702B3|2012-01-16|2013-02-21|Karlsruher Institut für Technologie|Optical coherence tomography with extended dynamic range|
    US9106191B2|2012-05-02|2015-08-11|Adaptive I/O Technologies, Inc.|Diode enhanced amplifier circuits and methods thereof|
    US8886697B2|2012-12-28|2014-11-11|General Electric Company|Solid state photomultiplier with improved pulse shape readout|
    US10527740B2|2014-04-03|2020-01-07|Siemens Medical Solutions Usa, Inc.|Silicon photomultiplier based TOF-PET detector|
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